Seismograph
by Jeff
Image text: The reverse only works if the subject has a nervous twitch.
This is another instance of the "pro tip" meme, which is designed to turn the reader into an expert from a novice in one easy step.
This comic is suggesting that if a lie-detector was placed on its side, that it would function as a seismograph to detect the size of earthquakes.
Collatz Conjecture
by Jeff
Image text: The Strong Collatz Conjecture states that this holds for any set of obsessively-hand-applied rules.
The Collatz Conjecture is a undecided or unsolved mathematical conjecture in which you have to do just as the comic says. However, the comic takes it one step further since this conjecture is unsolved, you can keep working on it (by hand) obsessively until you do not have any friends any more. Unless those friends want to come over and do math equations and conjectures by hand with you.
I Am
by Jeff
Image text: Great, LO-M. Do you speak Bocce? I'm supposed to find one that speaks Bocce.
The text in the first frame is a biblical reference as Abraham, Isaac and Jacob are all people from the Bible. The closest quote would be Exodus 3-5. The quote is from the burning bush passage in the Bible. It is possible the plant at the end of the tunnel could be a burning bush.
This comic is making an insinuation that the voice of God or God itself is C3PO from the Star Wars Universe.
In the Image text, the quote is from Star Wars: A New Hope in which Luke's uncle says the last two sentences of the image text to C3PO to make sure he speaks the same language as the moisture vaporators on their farm. Booce is the language spoken by those moisture vaporators.
The use of LO-M looks to be a double reference to Elohim which is used as the name of God in the Jewish religion and the LOM series droids from the Star Wars universe.
The tunnel could signify the Large Hadron Collider and the search for the "God" particle. The two particles falling behind the character in the first frame seems to signify that.
Sex Dice
by Jeff
Image text: You roll for initiative, and ... [roll] ... wow, do you ever take it.
In this comic, there are two different groups playing two different dice games. However, the dice got mixed up. Instead of numbers, the first two are supposed to have another die with actions on them, as seen in the last panel. The "sex" die got mixed in with the kids Dungeons and Dragons set because they did not organize the game cupboard. The four people in the last panel are completely different than the two in the first 3.
The joke in the image text is a play on the word "initiative". In Dungeons and Dragons you roll for initiative for an extra modifier to your roll of the dice. In the image text, they are suggesting that someone accidentally rolled a sex die for initiative. And "take initiative" means to take charge to take command outside of Dungeons and Dragons.