Scribblenauts
by Jeff
Image text: Let me look away and type 'guy who's just jealous that I beat all his MarioKart times' and turn back, and ... yup, there you are again!
Scribblenauts is a side-scrolling game for the Nintendo DS in which you can summon objects to help you in the game, such as a ladder, or plants. "A fundamental element of Scribblenauts is the ability of the player to summon myriad objects into the game. This is achieved by writing the name of an object on the touchscreen (or via keypad)"
This comic takes that one step further and pokes fun at the prospect of summoning a friend in Scribblenauts by the phrase "Pretentious Asshole" or "guy who's just jealous that I beat all his MarioKart times"
The first two frames are making mention of the fact that there was some fear that the large hadron collider in CERN in Europe would create a black hole through their experiments. This was widely debunked, but apparently in Scribblenauts in xkcd, it does make a black hole.
Oregon
by Jeff
Image meta text: A century later, the harrowing flight of the survivors from Oregon was dramatized in a popular video game.
This cartoon references the Oregon Trail computer game which every kid who went to elementary school in the 80s played in computer class. The best and most exciting part of this game for the kids was the hunting part.
This cartoon is speculating that if all these kids really travelled the trail, no one would have food because of the massive overhunting. Frequently, in the game, you would kill a 1000 pound buffalo, but you would only be able to carry 200 pounds back to your wagon, leaving the other 800 pounds to rot. I always thought that was odd.
And lastly, the cartoon recognized all the odd ways you and other members of your wagon could die in the game (often suddenly): dystentry, typhoid, measles, cholera. Unless you were a doctor in the game, but everyone knows being a doctor or banker is practically cheating.
Superlative
by Jeff
Image meta text: "Stay while I recount the crazy TF2 kill I managed yesterday, my friends."
Superlative is a comic that references the Dos Equis beer commercial which describes the "Most Interesting Man in the World." (youtube link)
The character in the comic is going through some of the most boring things in the world: recounting dreams to others, not speaking another language (the character in the commercial has been known to "Speak French in Russian"), making a blog with no content (first post!) and apparently drinking two beers and feeling sick.
The meta text is a reference to the Dos Equis tag line of: "Stay thirsty my friends." TF2 is Team Fortress 2, a video game available on consoles and for PC.