1130: Poll Watching
Title text: The choices we make Tuesday could have MASSIVE and PERMANENT effects on the charts on Nate Silver's blog!
This comic is another commentary on the 2012 U.S. presidential election (as 1122: Electoral Precedent and, to an extent, 1127: Congress also were references to), as it was posted the day before the election.
In the comic, Cueball is glued to his laptop reading media coverage of the election. The off-screen character's comic that Cueball should take a break suggests that Cueball has been reading media coverage for quite a while.
Cueball is so caught up in media coverage, that he is speculating on the effect that incumbant President Obama winning the election (and the resulting news coverage) could have on challenger Mitt Romney's campaign. The joke is that the end-goal of Romney's campaign is to win the election. If Obama wins, the campaigning is already over, regardless of media coverage. Cueball is simply so invested that he is over-analyzing potential scenarios.
In respect to the title text, Nate Silver is an American statistician, psephologist, and writer (among other things not-relevant to this comic). He has a political blog called FiveThirtyEight which was originally written under a pseudonym. The Blog and its associated website primarily discuss tracking polls in respect of elections. Thus, the choices made on Tuesday (election day) presumably will have massive and permanent effects on FiveThirtyEight's charts, which will obviously change to reflect the actual votes cast. This is a parody of the bold statements often made during campaigns, such as that the choices made on election day could have massive and permanent effects on such things as your health care, the economy, your job, etc.