explain xkcd - User contributions [en]

Talk:1217: Cells

2020-06-07T08:51:46Z

108.162.250.67:

One can test the cytotoxicity (the ability to kill cells) on a petri-dish level for cancer cells and healthy cells separately. However, this is often not done, knowingly neglecting selectivity issues one could face if the tests were done. This should be included in the explanation. The part that is written in the moment mainly explains the title text. [[Special:Contributions/130.60.152.125|130.60.152.125]] 08:34, 27 May 2013 (UTC)

:Sorry to correct you. Toxicity is tested for both, healthy cells an cancer cells. But as the targets for drugs are often present in both celltypes, the drug itself affect also both cells. Then you have to choose between certain death by cancer in short time and maybe death or side effects in the long row but survival. It's replacing one evil with another. Only very modern anticancer drugs (e.g. Gleevec) are selective enough to target (mostly) only cancer cells. The drawback is, as cancer in different people is not the same but different cells, you would need different drugs for everybodey affected. One way here lies in the personalized medicine, but that is very expensive...
[[Special:Contributions/195.37.27.58|195.37.27.58]] 10:05, 27 May 2013 (UTC)Richard

I've seen plenty of (academic, not industry) studies where tests on healthy cells were not done: The author present the synthesis of fancy new anti-cancer compounds XY, test it on HELA cells, see it is killing them, and publish this - even in high impact journals. This is a fact. [[Special:Contributions/130.60.152.125|130.60.152.125]] 11:09, 27 May 2013 (UTC)

I am pretty sure this comic refers to the most recent overhyped headline of that type 'Vitamin C kills cancer cells'. Since it sounded like a natural remedy it was very widely spread, and widely misunderstood.[[Special:Contributions/62.220.2.194|62.220.2.194]] 11:38, 27 May 2013 (UTC)

Oxygen kills cancer cells! Under high enough temperatures it reacts with organic molecules in cancer cells, and produces CO2, H2O and some other stuff. --[[Special:Contributions/81.23.24.43|81.23.24.43]] 12:28, 27 May 2013 (UTC)

Read environmentalists-how-to-tell-the-bad-ones-from-the-good[http://reformedperspective.ca/index.php/component/content/article/65-environmentalists-how-to-tell-the-bad-ones-from-the-good] as analogous on how people commonly are unable to decipher scientific information. [[User:Spongebog|Spongebog]] ([[User talk:Spongebog|talk]]) 20:51, 27 May 2013 (UTC)
:Hey, that's "A Canadian-based monthly Christian magazine". Randall and me do not accept this!--[[User:Dgbrt|Dgbrt]] ([[User talk:Dgbrt|talk]]) 21:23, 27 May 2013 (UTC)
::Sure, we can just go with the Snopes [http://www.snopes.com/science/dhmo.asp] version instead ... [[User:Spongebog|Spongebog]] ([[User talk:Spongebog|talk]]) 21:31, 27 May 2013 (UTC)
:::That April's fool is also a really old joke. "dihydrogen monoxide". H (hydrogen), two times - and O (oxygen) one time (mono...). My body and also yours too contains 60% of water. Any link to cancer? --[[User:Dgbrt|Dgbrt]] ([[User talk:Dgbrt|talk]]) 21:45, 27 May 2013 (UTC)
::::They are both dangerous to your health [[User:Spongebog|Spongebog]] ([[User talk:Spongebog|talk]]) 03:18, 28 May 2013 (UTC)
::[[User:Dgbrt|Dgbrt]] It would be "Randall and '''I''' do not ... " [[Special:Contributions/173.245.55.217|173.245.55.217]] 20:10, 11 December 2013 (UTC)BK201

Actually, oxygen is quite toxic to all cells, even though our cells will quickly die without it. A very large proportion of our physiological pathways are involved in the two tasks of (1) using oxygen to meet the energy needs of our cells while (2) protecting our cells from its toxicity. Outside our cells also, oxygen is both essential and dangerous: much of our technology would not work without oxygen from the air, but that same oxygen creates a fire hazard.
[[Special:Contributions/24.91.233.200|24.91.233.200]] 12:16, 29 May 2013 (UTC)

I think [http://www.thethingspatientssay.com/2012/08/why-i-hate-herbal-supplements.html supplements i hate]this blog post is particularly relevant to this article --[[User:Guru-45|Guru-45]] ([[User talk:Guru-45|talk]]) 02:18, 9 September 2013 (UTC)
: The link above just leads me to various fake sites.
:: [https://web.archive.org/web/20140109200324/http://www.thethingspatientssay.com:80/2012/08/why-i-hate-herbal-supplements.html This link] takes you to an archive.org mirror of the post [[Special:Contributions/108.162.250.67|108.162.250.67]] 08:51, 7 June 2020 (UTC)

696: Strip Games

2020-06-07T01:09:36Z

108.162.250.67:

{{comic
| number = 696
| date = February 1, 2010
| title = Strip Games
| image = strip_games.png
| titletext = HOW ABOUT A NICE GAME OF STRIP GLOBAL THERMONUCLEAR WAR?
}}
==Explanation==
The frequency of strip versions of various games is measured by means of Google search results. Strip versions of popular games are a common activity at parties, especially when alcohol is involved. The obligation to remove pieces of clothing is supposed to add an extra zest to the game. A very widespread variant is {{w|Strip Poker}}, followed by strip versions of regular party games like {{w|Truth or Dare}} or {{w|Spin the Bottle}}.

However, the comic also suggests playing other games in a way that involves stripping. In reality, playing such games as "Strip {{w|Tennis}}" or "Strip {{w|Agricola (board game)|Agricola}}" is rather unusual. ''{{w|Jumanji}}'' is a Robin Williams movie about a magical board game that manifests dangerous creatures and traps from the jungle and lost civilization therein; a theoretical Strip Jumanji would probably not remain very titillating during the chaos (evidently, therefore, "strip jumanji" refers to [https://jumanji.fandom.com/wiki/Jumanji_(Milton_Bradley_Board_Game) the real-life board game based on the movie]).

The last column features games of which strip versions are (according to Google) nonexistent. While the other columns named sports or board games where a strip variant would be at least conceivable, the last one includes the {{w|zero-player game|zero-player}} {{w|Conway's Game of Life|Game of Life}} and the {{w|Prisoner's Dilemma|Iterated Prisoner's Dilemma}}, which is a theoretical example in {{w|game theory}}. It is therefore left to the reader to imagine how a strip version of these pseudo-games would appear.

{{w|Poohsticks}} is a children's sport mentioned in the {{w|Winnie-the-Pooh|Winnie-the-Pooh books}} played by dropping sticks into a river and watching them reappear on the other side of a bridge. Despite the kid-friendly origins, and unlike the other games below it, a "strip" version of Poohsticks is actually viable.

[[wikia:w:c:starwars:Podracing|Podracing]] appears in the {{w|Star Wars}} films as a racing competition held with hovering vehicles. How a "strip" version would work between two racers is unclear, but a determined set of spectators "wagering" their clothes on the races could probably hammer out a system.

{{w|Chess by mail}} could conceivably work if the players include increasingly-nude photographs of themselves in their correspondences. The problem is, a game by e-mail can take days to finish, and a game by snail-mail can take upwards of ''several months''. The titillation factor is far too spread out to satisfy the desires of anyone who would elect to play a game of strip chess in the first place. It could be an interesting idea for a long-distance relationship, however.

"Global Thermonuclear War" in the title text is a reference to the film "{{w|WarGames}}", where a young hacker accesses a US military supercomputer and starts a nuclear war simulation, believing it to be only a computer game. The film ends with showing the computer that nuclear war is "a strange game" in which "the only winning move is not to play", and proposes "a nice game of chess".

Strip global thermonuclear war is a patently absurd idea; while it is a common trope for people to engage in one last moment of intimate pleasure before certain doom, foreplay (including strip games of any type) is a time-consuming practice, and time is something you don't have much of considering that the bomb could drop on your place of residence at any moment. Besides all that, the act of betting on which city is going to go up next in a nuclear inferno tends not to be an effective aphrodisiac for most people.{{Citation needed}} But at least you wouldn't be wearing your radioactive clothes!

==Transcript==
:Frequency of Strip Versions of Various Games

:n = google hits for "strip <game name>" / google hits for "<game name>"
:(at the time of this writing)

:Frequent
:(n > 1%)
:-Poker
:-Spin the Bottle
:-Beer Pong
:-Never Have I Ever
:-Truth or Dare

:Rare
:(1% >= n > 0.01%)
:-Chess
:-Blackjack
:-Tennis
:-Settlers of Catan
:-Pictionary

:Extremely Rare
:(0.01% >= n > 0)
:-Cricket
:-Magic: the Gathering
:-Stickball
:-Agricola
:-Jumanji

:Nonexistent
:(n = 0)
:-Poohsticks
:-Podracing
:-Iterated Prisoner's Dilemma
:-Chess by Mail
:-Conway's Game of Life

{{comic discussion}}

[[Category:Charts]]
[[Category:Sport]]
[[Category:Chess]]
[[Category:Nuclear weapons]]

Talk:2306: Common Cold

2020-05-15T00:45:04Z

108.162.250.67: Add Princess Bride reference

WHEN COVID19 IS DONE KEEP UP WITH THE HAND WASHING![[Special:Contributions/108.162.216.122|108.162.216.122]] 23:16, 13 May 2020 (UTC)

I saw a thing reshared some time last month claiming that after the hand-sanitizer-and-masks outbreak in Japan, some regions were recording record low numbers of influenza hospitalisations for this time of year. Thought that would be nice; but could only find unsourced claims. Would be nice to think there really was that kind of silver lining. [[User:Angel|Angel]] ([[User talk:Angel|talk]]) 23:30, 13 May 2020 (UTC)
:Since people are really staying away from each other, the only way flu and common cold can spread has also been eliminated. So of course the rate has dropped. But yes, would be nice to see some citations. --[[User:Kynde|Kynde]] ([[User talk:Kynde|talk]]) 12:13, 14 May 2020 (UTC)
::Found this [https://www.abc.net.au/news/2020-04-17/coronavirus-numbers-flu-tracking-data/12134082 Coronavirus isolation measures are reducing all flu-like diseases, not just COVID-19].--[[User:Kynde|Kynde]] ([[User talk:Kynde|talk]]) 12:15, 14 May 2020 (UTC)
::And this is more up to date: [https://www.straitstimes.com/singapore/health/coronavirus-doctors-see-huge-drop-in-flu-common-cold-diarrhoea-and-conjunctivitis Coronavirus: Doctors see huge drop in flu, common cold, diarrhoea and conjunctivitis cases since circuit breaker measures]. --[[User:Kynde|Kynde]] ([[User talk:Kynde|talk]]) 12:16, 14 May 2020 (UTC)
:::While this SEEMS good news, I have wondered for a while now if, by eliminating harmless cold viruses that our immune systems are more or less accustomed to as "collateral damage", we might not accidentally open up new ecological niches, which then get occupied by MORE new pathogens that our immune systems are NOT accustomed to. So, it may actually a good idea to consider that deal.... --[[Special:Contributions/162.158.159.122|162.158.159.122]] 13:50, 14 May 2020 (UTC)
::::I don't think cold viruses are thought to be part of healthy gut flora (or [[1471: Gut Fauna|gut fauna]]), but the "{{w|hygiene hypothesis}}" posits that failure to properly seed the microbiome in early childhood (i.e. not enough dirt in life) may lead to increased prevalence of allergies and other autoimmune disorders, because (perhaps) the immune system is under-exercised and so some of its regulatory mechanisms are under-developed. --[[User:NotaBene|NotaBene]] ([[User talk:NotaBene|talk]]) 15:02, 14 May 2020 (UTC)
::::By social distancing, we are not harming cold viruses more than anything else ; what we are doing is basically shrinking the ecological niche containing it. So, no ... unless we will be so good in it we really eliminate cold viruses and when we do, we will then stop social distancing and grow the ecological niche again. -- [[User:Hkmaly|Hkmaly]] ([[User talk:Hkmaly|talk]]) 22:16, 14 May 2020 (UTC)

According to Taiwan National Infectious Disease Statistics System, the [https://nidss.cdc.gov.tw/en/SingleDisease.aspx?dc=1&dt=4&disease=487a&position=1 number of severe influenza cases in Taiwan] was 109 on week 1 of 2020, then drop to zero since March. [[Special:Contributions/172.69.34.58|172.69.34.58]] 04:54, 14 May 2020 (UTC)

Based on the railroad's Twitter feed which announces when service is suspended because someone got hit by a train, it seems that deaths from being hit by trains are down where I live. I'd expect some reduction in accidental deaths due to fewer trains per day running. However, the reduction in deaths is greater than the reduction in train service, so that's not the full explanation, especially since most of the deaths were suicides.[[Special:Contributions/108.162.215.250|108.162.215.250]] 05:27, 14 May 2020 (UTC)
: Has the general rate of suicide changed? [[User:Barmar|Barmar]] ([[User talk:Barmar|talk]]) 16:35, 14 May 2020 (UTC)

Was this comic posted a day late? [[Special:Contributions/172.69.130.10|172.69.130.10]] 11:36, 14 May 2020 (UTC)
:No. But the DGBRt bot that uploads the comic is in the wrong time zone and there it was May 14th. But in the archive on xkcd it is listed as a May 13 release. I have corrected the wrong date. This has happened with two comics now over the last few releases. --[[User:Kynde|Kynde]] ([[User talk:Kynde|talk]]) 12:11, 14 May 2020 (UTC)

Current transcript indicates he is shouting the "no" in the last frame. I read this significantly more as an extremely forceful spoken word, not so much "THIS IS SPARTA!" [[User:OhFFS|OhFFS]] ([[User talk:OhFFS|talk]]) 16:04, 14 May 2020 (UTC)
:Agree. Fixed. [[User:N0lqu|-boB]] ([[User talk:N0lqu|talk]]) 21:21, 14 May 2020 (UTC)

I AM THE DREAD FAUCET ROBERTS. THERE WILL BE ''NO SURVIVORS''! [[Special:Contributions/108.162.250.67|108.162.250.67]] 00:45, 15 May 2020 (UTC)

Talk:2292: Thermometer

2020-04-11T04:31:01Z

108.162.250.67: forgot to sign

First non-Covid post other than April fools?[[Special:Contributions/162.158.107.167|162.158.107.167]]
23:04, 10 April 2020 (UTC)
:Since a fever is a common symptom of Covid-19, I'd say this is as much about Covid-19 as all the previous comics on the topic. [[User:Ianrbibtitlht|Ianrbibtitlht]] ([[User talk:Ianrbibtitlht|talk]]) 02:59, 11 April 2020 (UTC)

A common practice in schools and the like prior to quarantine was temperature taking upon arrival. So it's like that this comic continues that to the home setting. [[Special:Contributions/162.158.78.112|162.158.78.112]] 23:19, 10 April 2020 (UTC)

A pessimist would guess that this means someone in Randall's household has a fever. [[Special:Contributions/108.162.219.52|108.162.219.52]] 23:26, 10 April 2020 (UTC)

> The Physician Ducks[[Special:Contributions/172.69.62.94|172.69.62.94]] 23:32, 10 April 2020 (UTC)

Personally I'd welcome a home thermometer marked off in Kelvin, avois all the "twice as cold" sort of confusion you can get with an arbitrary zero as used in Celsius and Fahrenheit. [[Special:Contributions/162.158.34.210|162.158.34.210]] 23:21, 10 April 2020 (UTC)

I might have enjoyed a "Degrees of Kevin Bacon" joke in this comic somewhere. :-) [[Special:Contributions/172.69.68.143|172.69.68.143]] 23:42, 10 April 2020 (UTC)

Double-plus-dissapointed we didn't get the Delisle measure referenced at all... [[Special:Contributions/162.158.34.202|162.158.34.202]] 01:17, 11 April 2020 (UTC) ...and now added. It would be better in any Trivia section, but we don't have one so hoping it's no more out of place in the explanation as Fahrenheit. [[Special:Contributions/162.158.34.202|162.158.34.202]] 02:02, 11 April 2020 (UTC) ...''aaaand'' someone removed it (as pure trivia, of course), fair enough. Anticipated. Anyone still interested in what I put just needs to check this IP, at about this timestamp, in Page History, though, so not going to argue the point. [[Special:Contributions/162.158.34.202|162.158.34.202]] 02:08, 11 April 2020 (UTC)

No temperature scale is defined using melting or boiling points of water anymore. Since 2019 Kelvin is defined via the Boltzmann constant, and all other temperature scales have been (re-)defined relative to the Kelvin scale for quite a while. --[[Special:Contributions/172.69.63.103|172.69.63.103]] 01:24, 11 April 2020 (UTC)

Randall forgot the Réaumur scale.[[Special:Contributions/162.158.123.97|162.158.123.97]] 03:00, 11 April 2020 (UTC)

I'm not sure why some people seem to look for any opportunity to take a dig at the US, but I removed the line in the explanation about US-based readers not being familiar with the Celsius temperature scale. I'm sure most Americans are familiar with it but prefer the Fahrenheit scale instead. I don't understand why anyone holds that against us. [[User:Ianrbibtitlht|Ianrbibtitlht]] ([[User talk:Ianrbibtitlht|talk]]) 03:04, 11 April 2020 (UTC)

Regarding USA Fahrenheit and non-USA Celsius preference, I was in Niagra Falls a few years back, listening to a Canadian station on the radio (ok, more than a few years ago...) and the DJ gave a weather report, saying “The current temperature is 25 degrees, that’s 77 on the understandable scale.” [[Special:Contributions/173.245.54.201|173.245.54.201]] 04:22, 11 April 2020 (UTC)

I guess if you wanted to use the Newton scale you'd need to have Newton's original "degrees of heat" measuring device. [[Special:Contributions/108.162.250.67|108.162.250.67]] 04:31, 11 April 2020 (UTC)

Talk:2292: Thermometer

2020-04-11T04:29:25Z

108.162.250.67: comment on Newton scale