Editing 1526: Placebo Blocker
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==Explanation== | ==Explanation== | ||
− | This comic is a joke about the difficulty of testing a drug that is supposed to block the | + | This comic is a joke about the difficulty of testing a drug that is supposed to block the placebo effect. |
− | A placebo experiment is used for testing a drug candidate. It has two groups: one that gets a real drug candidate, and one that gets a fake. The placebo effect describes the observation that the group that gets the fake often show signs of having received a working drug - though commonly weaker than in the group that gets an effective real drug. | + | A placebo experiment is used for testing a drug candidate. It has two groups: one that gets a real drug candidate, and one that gets a fake. The placebo effect describes the observation that the group that gets the fake often show signs of having received a working drug - though commonly weaker than in the group that gets an effective real drug. In this comic, [[Cueball]] is trying to test a placebo blocker. |
+ | This means that the one that gets the real thing will think that they got it because they did, and the group that gets the fake will think that they got the real thing because of the placebo effect, and this makes [[Hairbun]]'s head hurt. | ||
[[Cueball]] states to [[Hairbun]], with a citation from the real world, that his team created a Placebo Blocker, a drug designed to prevent the placebo effect. Cueball begins to design a test for this new drug. Following typical experimental design, patients would be split into two groups: a control group, and the group that receives the treatment. | [[Cueball]] states to [[Hairbun]], with a citation from the real world, that his team created a Placebo Blocker, a drug designed to prevent the placebo effect. Cueball begins to design a test for this new drug. Following typical experimental design, patients would be split into two groups: a control group, and the group that receives the treatment. | ||
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Placebo-blockers do actually already exist. A side-effect of the opiate antagonist {{w|Naloxone}} is that it [http://healthland.time.com/2009/08/26/a-neurological-explanation-for-the-placebo-effect/ blocks the placebo effect]. | Placebo-blockers do actually already exist. A side-effect of the opiate antagonist {{w|Naloxone}} is that it [http://healthland.time.com/2009/08/26/a-neurological-explanation-for-the-placebo-effect/ blocks the placebo effect]. | ||
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===Mechanisms of the placebo effect=== | ===Mechanisms of the placebo effect=== | ||
− | The placebo effect is one of the greatest mysteries in modern medicine. It is typically found that the placebo effect is an effective treatment in itself in addition to the effectiveness of drugs and other treatments, and it has been found to cause small improvements to cancer outcomes. In other cases such as pain relief, the placebo effect is | + | The placebo effect is one of the greatest mysteries in modern medicine. It is typically found that the placebo effect is an effective treatment in itself in addition to the effectiveness of drugs and other treatments, and it has been found to cause small improvements to cancer outcomes. In other cases such as pain relief, the placebo effect is very large compared with the effectiveness of the drug itself. |
− | The comic refers to the recent study by Kathryn T. Hall, Joseph Loscalzo, and Ted J. Kaptchuk. (2015) ''[https://dx.doi.org/10.1016/J.MOLMED.2015.02.009 Genetics and the placebo effect: the placebome.]'' Trends in Mol Medicine. Volume 21, Issue 5, May 2015, Pages 285–294 | + | The comic refers to the recent study by Kathryn T. Hall, Joseph Loscalzo, and Ted J. Kaptchuk. (2015) ''[https://dx.doi.org/10.1016/J.MOLMED.2015.02.009 Genetics and the placebo effect: the placebome.]'' Trends in Mol Medicine. Volume 21, Issue 5, May 2015, Pages 285–294 |
− | It is possible to test the placebo blocker using three groups: a test group who receive | + | It is possible to test the placebo blocker using three groups: a test group who receive a placebo blocker, a control group who receive a placebo, and a second control group who receive no treatment whatsoever, as a lack of treatment is the variable that an actual placebo is designed to control for. Still it might be hard to determine if the pills are having a negative effect or blocking the placebo effect, so multiple trials with multiple illnesses may have to be carried out. |
==Transcript== | ==Transcript== | ||
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[[Category:Comics featuring Hairbun]] | [[Category:Comics featuring Hairbun]] | ||
[[Category:Science]] | [[Category:Science]] | ||
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