Editing 2425: mRNA Vaccine

This comic is another in a [[:Category:COVID-19|series of comics]] related to the {{w|COVID-19 pandemic}}, specifically regarding the [[:Category:COVID-19 vaccine|COVID-19 vaccine]].

This one is another analogy to how {{w|mRNA vaccines}} work, by creating inactive fragments of the virus to prime the immune system to be prepared to stave off the real thing. This is done in response to Cueball's question to the person vaccinating him, "Why would my body attack something it made itself?", using elements of the film ''{{w|Star Wars (film)|Star Wars: Episode IV}}'' as an analogy.

The analogy starts in the second panel, where the Rebel Alliance has retrieved the {{w|Death Star}} plans, conveyed by {{w|Princess Leia}} to General [https://starwars.fandom.com/wiki/Jan_Dodonna Jan Dodonna] (in ''Star Wars'', via {{w|R2-D2}} and some adventures, but shown as a simple handoff here). The Death Star is a space station the size of a small moon that has the power to destroy planets. In the film, the plans are analyzed to find a weakness in the enemy Death Star and destroy it; however, in this panel, the "Death Star plans" are passed down a line of people until they are interpreted as a construction assignment and are used to build a Death Star. In the analogy, the mRNA in the vaccine corresponds to the plans for the Death Star, the spike proteins (inactive COVID-19 virus fragments) correspond to the benign Death Star itself, and the cellular processes that build spike proteins correspond to the builders of the benign Death Star.  Just as merely having the plans on hand led to the Death Star being built, the mere presence of the mRNA in the cellular environment leads to it being translated, producing the viral protein.  Amusingly, as the plans are handed off to the construction crew leader, he replies "Copy that," which both acknowledges the handoff in conversation and presages his actions.

After Leia's Death Star has been built, it is positioned near a planet/moon. This Death Star is ''benign'': it only ''looks'' dangerous and isn't about to actually hurt anyone; the Death Star crew are Rebels, after all, and state that they don't have the laser wired up. The Rebels mobilize to destroy this benign Death Star because it looks like an enemy battle station, evidently not listening to the construction crew's transmissions. Analogously, immune cells cannot think {{Citation needed}} or directly communicate, basing their determination of friend from foe entirely on external chemical signatures. However, the Death Star operators are confused, because they believe Leia (a member of the Rebels) had ordered its construction. The Rebels initially attack the surface of the benign Death Star, without much effect; Leia orders the factories to continue developing torpedoes and ships as they run out, presumably putting an extra workload on the factory workers and tiring them out, or at least diverting resources away from other projects. In the analogy, the Rebels correspond to the immune system's {{w|B cells}} and {{w|T cells}}, which mobilize to attack the spike proteins (the benign Death Star) made as a result of the vaccine, but are often ineffective at first. The body keeps producing these immune cells, trying many variants (many ways of attacking the benign Death Star) in an attempt to find one that works well against the spike proteins. This results in Cueball experiencing {{w|side effects}} from the vaccine, including soreness and tiredness, and he lies down and rests.

After much effort on the Rebels' part, they find a weakness in the benign Death Star, a "thermal exhaust port" vulnerable to "proton torpedoes" that can destroy the Death Star. Firing a proton torpedo down the exhaust port destroys a Death Star very rapidly, compared to the initial, ineffective frontal assault on the surface. After this benign Death Star is destroyed, Princess Leia allows the fleet to stand down.  

Up to this point, the entire thing seems like a comedy of errors, with huge expenditures being made for no apparent reason, due to a simple lack of communication. But during this process, the Rebel Alliance has both built a huge fleet and figured out how to target the Death Star's weakness and destroy it. Later on, when a real, dangerous Death Star approaches the planet (with the apparent intent of destroying it), the Rebels immediately deploy their fleet, target the weakness, and destroy it almost immediately, much to the shock of the Imperial troops, who had believed they were on an invulnerable ship and are surprised by the Rebels' immediate response and overwhelmed by it.

The analogy is that the immune system (the Rebel Alliance) figures out a way to attach to the spike proteins (attack the benign Death Star) made by the mRNA vaccine; the immune system's {{w|antibodies}} (Rebel planners) now "know" how to recognize and destroy things that have these spike proteins — including SARS-CoV-2 virus particles (real, dangerous Death Stars). Hence, when the vaccinated Cueball approaches White Hat, who is maskless, coughing, and presumably sick with COVID-19, Cueball's immune system is able to destroy dangerous SARS-CoV-2 virus particles because it knows about the virus's spike proteins. This is represented by Cueball not experiencing any suffering from COVID-19, and he goes on his way whistling merrily, perhaps to the tune of [https://www.youtube.com/watch?v=yixG8pfncOs The Throne Room/End Title] (from the ceremony celebrating the destruction of the Death Star).

 

 

Vaccination was also explained, xkcd-style, in [[2406: Viral Vector Immunity]].  

 

References to the ''{{w|Star Wars}}'' franchise are a [[:Category:Star Wars|recurring theme]] on xkcd.

:[Princess Leia and General Dodonna in frame.]

:Dodonna: Thank you, Princess.

:[Dodonna, Ponytail, and White Hat in frame.]

:Dodonna: These blueprints are from Princess Leia.

:[Ponytail is standing still and Princess Leia is walking to the right with her fists raised.]

:[A disheveled Dodonna, Princess Leia, and Ponytail in frame.]